The food allergy is frequently the beginning of the long march of the allergy

Even if a food allergy frequently disappears with age, it is unfortunately far too often the beginning of a chronic illness that is characterized by the immune system reacting to various triggers (allergens) mainly with acute inflammation symptoms (eyes, conjunctivitis, runny nose, inflamed nasal mucosa etc.). The long march clearly indicates that the allergy was not caused by allergens but by the immune system itself revealing dysfunctions or problems with dealing with the environment, which become particularly noticeable when we come into contact with the triggers (allergens) through the skin or mucous membranes.

Have a look at the experiences of our Biest athletes…

The next stops of the march are asthma and hay fever

If one analyses the path of the allergy, how it continues almost in accordance to law, then it really looks like the allergy distributes or relocates itself from a center, namely the bowel, into the periphery. The bowel is the first organ at birth that is massively confronted with the environment, not only through food but also through a large number of germs and particles of all kinds.
The immune system starts to mature in the bowel, where the first borders of the individual to the outside world develop. There, a balance between activating and restraining immune processes should develop. In the first weeks and months of life, this balance is produced by breast feeding, lactic acid bacteria and bacteria from the ground from the food that slowly replaces breast milk, but also by cat hairs and house dust or infections suffered from.

In a nutshell, that means:
Right from the beginning of our life, and at exactly the right point in time of our development, we have to encounter those substances that should become part of our organism. If this doesn’t happen, we can become allergy-sufferers. Thus, the allergy describes a changed condition of activity of our immune system, thus an immune regulation disorder and not a disorder caused by allergens. If one considers the allergy as a disorder of the immune system, then one will not be surprised about it being able to spread out to other organs at any time. Which of these processes can go wrong in detail in the first weeks of life is something we know very little of today. Unfortunately, it is difficult to correct this later on in life, if at all. If one suffers from an allergy, then increased strains on the immunity can stimulate the allergy.

Treat allergies with Biestmilch and stabilize the immune system

Conventional methods of treatment are antihistamines, cromoglycin or desensitization. All 3 therapeutic strategies start with the allergens and not the unsound immune system. Biestmilch is different. Biestmilch modulates your immune system, influences the unsound regulation and can stabilize the immune system.
Biestmilch is a foodstuff and is perfectly suitable to abate allergic symptoms or make them disappear. Besides its modulating effects on the immune system, Biestmilch is also anti-inflammatory.

It doesn’t matter what allergies you suffer from and what causes are behind them, you are always afflicted by the same type of symptoms:
• Hay fever
• Conjunctivitis
• Asthma
• Eczema
• Digestives disorders

Instructions for taking Biestmilch – Recommended amount

You should take Biestmilch every day. Integrate it into your daily diet. Don‘t stop taking it.

1. Those with a pollen allergy
If you don’t have any symptoms yet, then start off with 900 mg a day and do that for about 3 to 4 weeks before your allergens become active. If the pollen count is particularly high or if you are under particularly great amounts of stress, the symptoms can emerge. In such a case, increase the dosage by 3- to 4-times the amount. After the symptoms have disappeared again, go back to the original amount. Do that until the season of your pollen has passed. You can also sniff Biestmilch powder when your hay fever is particularly bad.

2. Those with a food allergy
Irrespective of the allergens causing the food allergy, take 900 mg of Biestmilch on a regular basis. Usually things have calmed down after about 6 weeks. If you have a food allergy with proven positive immunoglobulin (IgE), the effects can be easily observed in the decrease in the IgE. After 6 weeks, you can carefully try out whether you can eat what you weren’t able to eat beforehand. Wait 4 days after the first test and then repeat the whole thing again with a larger amount.

3. Those with a contact allergy
If you suffer from allergic skin reactions, then your skin reflects the improvement or worsening fast. Start taking Biestmilch slowly (150-300 mg). Increase the dosage step by step until the skin reacts. The result can be a worsening in the form of a healing reaction. Be patient and stay on the ball.

The BOOSTER with its 4 grams of Biestmilch, is exactly what you need, if the allergy symptoms deteriorate. Allergies go along with fatigue. Biestmilch and guarana work in synergy, and improve your energy level. Biestmilch itself is energizing, the feeling of having more energy available is not only due to the guarana.

We have ALLERGY Promotion Week:  “Everyday Balance”  will be available for a special price.

Hard to believe but true, the BIEST BOOSTER is a high-tech product even though it is also a truly natural product. Biestmilch is natural through and through and so are the 100 mg of caffeine contained in the Booster and the sweetener Stevia. They originate from the natural caffeine extract of the guarana fruit and the stevia plant form North and South Amercia. The BOOSTER’s matrix is composed of a dextrose derivative called Emdex®. So in the end, what makes the Booster a high-tech product, is the art of combining 4 grams of Biestmilch with 500 mg of Guarana extract into an edible small shape.

The steps to its nowadays shape and composition

The idea of designing a product that may be able to facilitate the a breakthrough for Biestmilch, had been on our minds for quite some time. Even back in the first days of Biestmilch back in the year 2000, we had thought a product that would able to generate instant gratification for our customer, while Biestmilch regular takes 10 days up to round about 3 weeks to kick in.
After a couple of years of experience we decided to take up the idea of »a product for the impatient« again. We knew enough about Biestmilch and its efficacy to finally dare to develop such a product.

We knew that 4 grams of Biestmilch lift the spirits and help to improve the general well-being under the various conditions such as issues with immunity. Guarana is well known to you as a natural caffeine extract and stimulant supporting cognition. Now the basic idea was there and along with it the problems that usually emerge, when moving from theory to reality. All of a sudden the Biestmilch powder put up some resistance. So did the sorbitol, shape, structure, taste, solubility, brittleness and stability… a number of various problems suddenly popped up and put our theoretical concept to the test.

How to put 4 grams of Biestmilch into an edible shape?

In April 2006 we developed granules, which were neither edible nor possible to swallow in the respective amount. It foamed and frothed inside the mouth in a strange manner and gave any observer a hearty laugh.
As we already had some experience with developing bars, the next test product was a bar with 4 grams of Biestmilch and 500 mg of Guarana. The tiny Biest Booster bar was finished by June 2006. It tasted of bitter orange and was a bit hard, but we quite liked the taste. I am afraid to add, that we remained the only people with this opinion.

A chocolate coating gave the Booster a tastefulness that threatened the healthy aspects of our product. To much guarana may induce flushes, headache and restlessness. We took a step back from this kind of Booster. Another reason to distance ourselves from the bar was that we would then be compared with the gigantic market of bars. But the Booster is unique and incomparable, so we moved to the next testing phase.
In September ’06 we had made it to the first tablet, a square block. It was based on a sorbitol matrix. Because of its laxative effect, if consumed in large amounts, sorbitol was not exactly an option. And sorbitol has a rather narrow bandwidth concerning stability and consistency. Once the machine was even run down, because the block was simply too thick and the sorbitol jammed the machine’s extruder. So we had rock hard bricks, with which one could have very well killed somebody.

Back to re-thinking and testing

This thinking and testing process resulted in the first octagon version. The experiments lasted from February till April 2007. A huge breakthrough for the Booster development was the choice of the matrix Emdex® instead of sorbitol. Emdex® is a very modern dextrose derivative and a far better matrix than sorbitol. Taste and feeling in the mouth were improved greatly. At last, after a series of 8 to 10 different kinds we ended up with a product that could be considered for a broader range of testing. We still had massive problems with the stability of the tablet when trying to pack it. The octagon constantly broke into two pieces when put into the side sealed bag.

When eating the 7,8 g heavy Booster we also still had the problem of a kind of »suffocating sensation« and taste of mouth.

Series 11 brought the final breakthrough

Instead of Biestmilch powder we used agglomerated colostrum. In this testing series all of a sudden the Booster was stable and good to chew. Series 11.1 and 11.2 were mere variations in taste and mouth feeling to optimize »edibility«. With the Booster 11.2.4 the final decision was made for marketing the product. A first production of 4200 pieces left the factory in August 2007.

Since then we have been fine-tuning still, and worked on the mouth feeling. All the years that passed by until today show that those who once tried the BIEST BOOSTER and felt the instant positive effects become loyal consumers.
But the slight bitterness of its taste has ever since been a handicap for the first time user in specific.

Finally the BIEST BOOSTER’s bitterness is gone!

Since the beginning of the year it is legal to use Stevia in Germany. Now, finally we could take the last step in the BOOSTER’s development until now, add a very very little amount of Stevia to it. Stevia is 400 times as sweet as sugar. So we had to be very careful in applying it. Now its done, no bitter taste anymore, enjoy chewing the new BOOSTER!
But as you all confirmed in the passed tests the BOOSTER should not become really sweet. So what we did is we only removed the bitter part. The BOOSTER should be still a relief for your gustatory sense that after all the sweet gels and bars you eat.

Guaraná – a slow-release caffeine stimulant

Guarana from the Portuguese guaraná (Paullinia cupana) is a climbing plant in the maple family, native to the Amazon basin and especially common in Brazil. Guarana features large leaves and clusters of flowers, and is best known for its fruit, which is about the size of a coffee bean. As a dietary supplement, guarana is an effective stimulant. It contains about twice the caffeine found in coffee beans (about 2–4.5% caffeine in guarana seeds compared to 1–2% for coffee beans). Compared to the caffeine from coffee beans caffeine in guarana is slowlier released and is therefore active between 4 to 6 hours.
As guarana is rich in caffeine, it is of interest for its potential effects on cognition. In rats, guarana increased memory retention and physical endurance when compared with a placebo. A 2007 human pilot study assessed acute behavioral effects of guarana extract. Memory, alertness and mood were increased confirming previous results of cognitive improvement following the consumption of guarana.

Products with natural caffeine content

• a cup of coffee (150 ml) contains ca. 30 to 100 mg a small Espresso (30 ml) ca. 40 mg caffeine.

• a cup of black tea contains an average of 50 mg

In former days the caffeine in tea leaves was called theine, chemically its exactly the same as the caffeine in coffee. Only 100 g of dried tea leaves contain more caffeine than the same amount of roasted coffee beans.

• Guarana contains 4 to 9 g caffeine per 100 g dried weight.

• Cacao contains with 6 mg per cup a little bit of caffeine, but mainly theobromine.

• Chocolate contains caffeine as well (milk chokolate ca. 15 mg/100 g, bitter choclate ca. 90 mg/100 g), moreover theobromine and other stimulant substances.

It is now for decades that oxygen free radicals have been appointed as the cause of many ailments ranging from Parkinson’s disease to cancer to DNA damage and aging. Their positive role within the cell’s metabolism got more and more lost the more antioxidant supplements were marketed. Oxygen free radicals (ROS) play an important role in cell signaling, cellular respiration and homeostasis. The body possesses various buffer systems that neutralize ROS. The balance between both is essential for well-being. The question the cited study raises is whether substitution of antioxidants may harm this delicate balance. The study looks at training effects in specific, and is therefore of great interest for endurance athletes and their diet.

At first glance the study confirms the general consensus that acute physical exercise induces the generation of reactive oxygen species in muscle cells, or better depending on the state of exertion in all body cells. Because of that, it has been generally accepted over the past 20 years that increasing the concentrations of antioxidants within a muscle cell should provide greater protection against these oxidizing agents that have been assumed whether justified or not to induce fatigue. After the publication of the results of respective study the functional significance of exercise-induced oxidative stress should be open to discussion not only among scientists. Now  results from several other laboratories followed that underscore as well that ROS are signals that foster the expression of a number of genes necessary for muscle adaptation, one of the desirable processes that training is there for. Moreover the augmentation of the endogenous antioxidant buffer systems in response to regular training exerts beneficial effects in the prevention of chronic disease processes.
Aerobic exercise capacity is a stronger predictor of mortality than are other established risk factors.

The maximal capacity to take up, transport and utilize oxygen during exercise is known as VO2max. Large-scale epidemiologic studies of humans with and without cardiovascular disease show that low aerobic exercise capacity is a stronger predictor of mortality than are other established risk factors, such as diabetes, smoking, hypertension, or chronic obstructive pulmonary disease. In other words regular workouts that are increasing the aerobic exercise capacity are the major column on which well-being and longevity are based.
In this context proper mitochondrial function is an important mechanism that improves aerobic capacity. The relations among VO2max, muscle oxidative capacity, endurance capacity, and maximal aerobic workload capacity have been discussed for years. It seems that muscle oxidative capacity (ie, the mitochondrial content of muscle) is a major determinant of endurance capacity, whereas VO2max is only indirectly related to endurance capacity.

Vitamin C modulates endurance capacity but not maximal oxygen uptake after training

The aim of the here cited study was to explore the effects of vitamin C administration on training-induced increases in VO2max and endurance capacity and on the skeletal muscle mitochondrial biogenesis in both rats and humans. The results of this study showed that the maximal rate of oxygen consumption (VO2max) increased significantly after 8 weeks of training  in the non-supplemented and in the with vitamin C supplemented group. Already in 1999, Nielsen et al. found that supplementation is not superior to non-supplementation if it comes to VO2max in triathletes. Similar have been the results in this study performed in animals.
Endurance capacity is mainly dependent on the mitochondrial content of skeletal muscle (muscle oxidative capacity), not on VO2max which represents more a cardiovascular adaptation factor. To determine the effect of the antioxidant administration and exercise on the mitochondrial muscle content a series of experiments was performed in rats.
The animals were divided into to training groups on a 3-weeks and a 6-weeks endurance training protocol. Six weeks is approximately the period required to achieve a new steady state of the mitochondrial content in response to endurance training. In this study, endurance-trained rats showed a clear increase (186.7%) in their endurance capacity while the administration of vitamin C dramatically decreased this adaptation to only 26.5%.
One of the main conclusions from that study was that the mitochondrial content of the muscle is a major determinant of endurance capacity. The study suggests that for example an antioxidant such as vitamin C decreases the normally by exercise induced biogenesis of mitochondria and the antioxidant capacity of the skeletal muscle. There are even indications that vitamin C may increase the production of reactive oxygen species (prooxidant), but data is still inconclusive.

Antioxidant vitamins impair training efficiency

Free radicals are essential signals in muscle cell metabolism, antioxidant vitamins may interfere with this signaling processes. It is important to consider that free radicals are not always damaging to cells. In many cases, they serve as signals to adapt muscle cells to exercise via modulation of gene expression. This study once and again gives strong evidence that training brings about an increase in 2 major antioxidant enzymes (superoxide dismutases, glutathione peroxidases) in skeletal muscle and that Vitamin C obviously prevents these beneficial effects of training.
As already mentioned exercise itself is an antioxidant, because training increases the expression of 2 antioxidant enzymes related with longevity. The study results show that the continuous presence of small stimuli, such as low concentrations of ROS, augment the concentration of antioxidant enzymes. For this reason low concentrations of radicals may be considered to be beneficial, because they act as signals to enhance defenses, rather than being deleterious, as they can be when they are present at higher concentrations.
Supplementation with vitamin C lowers training efficiency. This can be seen as the major conclusion of this study. It is known that endurance capacity is directly related to the mitochondrial content. Mitochondria synthesis is seriously hampered by antioxidant supplementation. This does not apply to VO2max, which is related to cardiovascular system adaptations. This distinction to me seems important to be aware of.
For nutritionists who must prepare diets for athletes whose performance is dependent on their endurance capacity the results of this study should be seriously taken into consideration. For me the results are yet another strong indication that the body is a huge and complex regulatory system and substitution not necessarily the right way to deal with it adequately.

Interesting observation/facts that you should know

It should be taken into account that some of the world’s best marathon runners exhibit rather modest measures of VO2max. This for me is one proof that there are other parameters of importance that are responsible for endurance capacity. One but only one is the content of skeletal muscle mitochondria.
Antioxidant supplementation is very popular among athletes, but data showing any beneficial effects on muscle function of this type of widespread practice are elusive. In fact, several reports have shown deleterious effects of antioxidant treatment. As early as 1971, it was shown that vitamin E supplementation (400 IU/d for 6 wk) caused unfavorable effects on endurance performance. In 1996 and 1997, a Scandinavian journal published 2 reports showing the deleterious effects of ubiquinone-10 supplementation on the performance of humans after a high-intensity training program. In 2002, it was shown that supplementation of racing greyhounds with 1 g vitamin C/d for 4 weeks significantly slowed their speed. Taking into account that a high fitness level is associated with a lower risk of premature death from any cause, the effect of vitamin C administration on endurance capacity has important implication for nutritionists, physicians, and exercise trainers and practitioners. Thus, the common practice of taking vitamin C supplements during training (for both health-related and performance-related physical fitness) should be seriously questioned.

Source: Mari-Carmen Gomez-Cabrera, Elena Domenech, Marco Romagnoli, Alessandro Arduini, Consuelo Borras, Federico V Pallardo, Juan Sastre, and Jose Vina: Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr 2008;87:142–9. Printed in USA. © 2008 American Society for Nutrition

Am J Clin Nutr-2008-Gomez-Cabrera-142-9

Antibiotics are commonly used to treat sinusitis, an inflammatory illness that can be viral and/or bacterial. A new clinical trial has now found that a placebo works just as well.

Scientists randomized 166 adults, all of whom met the diagnostic criteria for sinusitis. One group of patients received the antibiotic amoxicillin the other a placebo three times a day for 10 days. On the third, seventh and tenth day, the participants recorded their symptoms.

There was no significant difference between the two groups in the amounts of time missed from work or everyday activities, relapse or recurrence rates, adverse effects or satisfaction with the treatment. Nor was there any difference in self-reported improvement in symptoms, except on the seventh day, when 74 percent of those taking amoxicillin reported improvement, compared with 56 percent of those on the placebo.

The authors acknowledge that it is possible that not all patients in the study had bacterial sinusitis, since the diagnosis is made clinically, not by a laboratory test (as mentioned in my article antibiotics are ineffective against a viral infection).

“I hope that the results here will give doctors evidence to use in discussions with patients about avoiding unnecessary antibiotic treatment,” said the lead author, Dr. Jane M. Garbutt of Washington University in St. Louis.

The study appeared last week in The Journal of the American Medical Association. As athletes you should be very careful when choosing antibiotics as a therapy option. At first sight it seems to be the safe way out for both parties, the physician and the patient. The longterm consequences such as multi-resistant bacteria are well known but not much cared of in the specific case.

Since we find ourselves at least on the Northern hemisphere in the midst of the high season of flus and upper respiratory tract infections, I thought that this is exactly the time to talk about infections and their standard treatment with the antibiotics. In my opinion this topic and its many discourses entangled with it leave us behind with a lot of misconceptions, uncertainty and ignorance. Antibiotics resistant species and strains of bacteria became one of the major threats in curing infections in the hospital environment, and are spreading into the communities, examples are tuberculosis and Staphylococci infections, Escherichia coli, Salmonella enterica, and Klebsiella pneumoniae.

The following article picks up some interesting aspects of the very recent scientific knowledge, only in brief and only in fragments, because the topic is huge, and can easily fill books’ pages. I want to outline the current status quo and future visions based on todays views. This should be our concern, because each of us could one day be a victim of this development.

In community medicine antibiotics are still the quick and easy fix

Even though, it seems that the awareness of the dangerous development of treatment resistant bugs is wide-spread, and talked about a lot by physicians, biologists and media, reality reflects otherwise. Whenever a physician feels insecure about a patient’s symptoms that he assumes are related to a microorganism antibiotics are in quick and close reach. A sore throat, a severe cough lasting for some days, and here we go, the prescription for an antibiotic is quickly written, and doctor as well as patient feel safe.

Patients nowadays are not patient enough anymore to give the body the time for healing. This is of course not only their fault. Our fast moving society often doesn’t allow us to stay home for a week, the time it mostly needs to recover from an acute (in most cases virus) infection. The ability to assess the risk, the ability to interpret body signs and take action accordingly got lost in many ways. Fever turned into a phenomenon that scares people, lungs became scary monsters that people are afraid may affect the heart. Joint pains may be suspicious of a rheumatic disease etc. etc…

Unfortunately, the knowledge our ancestors about what to do in cases of acute infections got almost lost. Moreover, many of us prefer to hand over the responsibility to the doctor.

Therefore we go and see the doctor for illnesses that usually disappear by itself and don’t need medical treatment. At the doctor’s two fears collide. Ours, we don’t want to die and the doctor’s, he doesn’t want to make a mistake and disappoint the patient or even get sued. In this setting antibiotics became a quick and efficient fix.

The dilemma starts where antibiotics are not seen as chemical compounds that are active in a bacterium within a body and an environment

There is a profound misconception here. Therefore let’s put the definition antibiotic at the very beginning of this article. Any class of organic molecule that inhibits or kills microbes by specific interactions with bacterial targets, without any consideration of the source of the particular compound or class can be called an antibiotic. Thus, purely synthetic therapeutics are considered antibiotics.

The meaning of the word changed over the decades. Today common sense connects antibiotics and its meaning with an agent that is ridding us of bugs of all kinds. Back in the days of their discovery the term antibiotics simply described its use, its laboratory effect, or its activity as a chemical compound. The term antibiotic does not say anything about its mechanism of action.

Unfortunately, due to ignorance and fear antibiotics are administered neglecting its mode of function and its effects within the bacteria, the body and the environment. The interactions of the antibiotic, the targeted microorganism and the body are not part of the medical discourse between patient and doctor. The problem of the development of resistant strains is located somewhere outside, far away from the individual situation of the patient. Antibiotics are basically for the good of the patient. Rarely we are aware of the fact that these compounds are actively spread in our environment with the detrimental consequences of resistant bacteria and the emergence of a bacterial monoculture destroying the healthy balance of microbial diversity.

Antibiotics became an unquestioned therapeutic fact. The harmful sides of this medication seem to me to be a discourse that became completely disconnected from the patient’s and doctor’s actual therapeutic interactive environment.

Antibiotics interact with the metabolic pathways of bacteria while viruses interact with the cell and don’t respond to antibiotics

At this point we are right in the center of the misunderstanding. Far too many antibiotics are prescribed without differentiating between viral and bacterial infections. Antibiotics cannot interact with viruses, because viruses don’t have an apparatus for the biosynthesis of the molecules the antibiotics interact with. The virus needs a host’s cell to do this job for it. Viruses integrate themselves into a living cell. They can do this on many levels from the nucleus to the cell, to its membrane. The virus and its metabolites can take over the control of the cell and its metabolism, and change the cell’s dedicated function. Viruses replicate by using the cell synthesis machinery, then virus metabolites and viruses spill an organ, an organ system, or the whole body. An acute virus infection may be the apparent phenomenon.

Or, the virus does not succeed to conquer the cell immediately, but silently integrates itself into the cell, and may finally induce a mutation in the nucleus or a change in one of the many signaling pathways of the cell. This mutation or change can lead to optimizing the cell functions or it can on the long run be deleterious for the cell, the organ or the organism by inducing a chronic virus infection or contributing to the emergence of a tumor.

Bacteria are not good or bad per se, nor is hygiene, we need to see the environment

Now, back to the antibiotics that are intervening with the biochemical pathways of the bacteria. To understand the many problems we face today due to the irresponsible use of antibiotics we have to have a rough idea how bacteria tick and survive on this globes for trillions of years. Men and bacteria coexist in a symbiotic way ever since. Our gut contains more bacteria (more than 500 species identified until today) than our body cells, and there are other mucosal linings colonized with bacteria that play an integral part in keeping our body in balance. Everybody got his or her very own microbial ecosystem. This means that my gut’s E. coli which is non-pathogenic for me, may induce an illness in you.

Thus bacteria play an essential role in our well-being. They may even be at the very beginning of more complex life, when cell fusions finally lead to complex organisms. Recent research discovered receptors on human cells that are either identical with bacterial elements or exactly mirror bacteria. These receptors make an essential part of our innate immune system by identifying bacterial components. It is well known today that our immune system displays patterns of receptors on immune cells that are able to recognize all common species of bacteria. This was a very brief outline of the positive aspects of bacteria, and now the negative ones, when bacteria turn against us.

Bacteria became almost synonymous for evil and dirty. This is not amazing if we go back in history when thousands of people died from bacterial infections often in their very early years. We thought to have solved this problem after having discovered antibiotics. Everybody knows that this was not the case, and if we don’t take care, we may even fall back into the pre-antibiotic era.

Here it is the double-edged sword: hygiene was one of the biggest steps forward in making our health care systems working successfully, on the other hand this same hygiene is turning against us. The soil’s and the air’s microbial ecosystem drifted out of balance. The balance among the many species and strains of bacteria controlling and constraining each other went berserk. Like in our flora we push the world of bacteria from diversity to monoculture. One phenomenon is the emergence of antibiotic resistant bacteria strains and species, another may be the increase in allergies and autoimmune diseases (another topic, another article!).

The realm of bacteria is a tightly interwoven communication network

The bacteria and their organizational principal accounts for many of the issues we have with antibiotics. We could have known better much earlier if our distortion field had not been so rigid. Only in the past few years has it been appreciated that gene exchange is a universal property of bacteria that has occurred throughout eons of microbial evolution. As mentioned already above the discovery of bacterial gene materials in the nucleus of cells including those of humans gives strong evidence about the great importance of horizontal gene transfer in the evolution of the genome on the one hand, and the organization of the bacterial collective on the other.

The way bacteria are communicating with each other, how they are able to exchange genetic materials, and the fact that they are producing antibiotics and express antibiotic resistant genes themselves indicates that the problem of resistance is integral part of the problem when dealing with bacteria and antibiotics.

Obviously resistance was always there, perhaps it is a question of survival for bacteria.

Accelerated emergence of resistance is the downside of one of the most valuable discoveries of mankind

Penicillin was discovered by Alexander Fleming in 1928, and in 1940, several years before the introduction of penicillin as a therapeutic, a bacterial penicillinase was already identified. Once the antibiotic was used widely, resistant strains capable of inactivating the drug spread. This phenomenon kicked off huge research efforts to find other compound that may evade cleavage by penicillinases. Only now, knowing what we know makes us appreciate and assess the value of the identification of a bacterial penicillinase before the use of the antibiotic. Recent findings confirm that a large number of antibiotic resistant genes are components of natural microbial populations. Are antibiotics and resistance an inseparable couple?

Let’s have a more closer look on these small creatures. Let’s not forget that they are alive and herewith possess their own genome and their own metabolic system that produces and secretes a large number of molecules, molecules of which we know only very little about. Bacteria possess pumping systems that prevent intracellular accumulation of molecules that may be able to kill or freeze them. The coexistence of synthesis and resistance functions in one and the same bacterium has been confirmed in recent studies. It seems logic to us that resistance is a mechanism of protection, an element of the bacterium that is needed for its chemical equilibrium.

It is a completely different story to look at bacterial monocultures in a lab or at bacteria in the wild

Only recently scientists started to study microbes in their natural environments. And it occurred what usually occurs when you leave the lab and have a glimpse on nature: you change your mindset and then your working hypothesis, and so it happened to the scientists observing bacteria in the wild.

They saw the large number of bioactive microbial compounds they produce, and found a lot of open questions they try to find the answers for now. Antibiotic activity was only one of the biological properties of the many bioactive small molecules. They exhibit extensive multi-functionality and most likely are involved in cell-cell signaling within and among the network of bacteria and other organisms in the environment (fungi, plants, insects, and even human and animal hosts). Researchers changed their path while investigating the interactions within complex bacterial communities (microbiomes) in different environments. They realized that many diseases occur as the result of polymicrobial infections, and they are working now on the implications of these observations.

If we look at the so-called resistance mechanisms from the standpoint of an antibiotic that lost its effects resistance gets a negative flavor. If we look at it from the perspective of a bacterium the process of “resistance” may facilitate cell-cell interactions, protect natural degradation pathways, or other functions we don’t know yet.

Some scary examples that should make us think when to use antibiotics or please, no antibiotics in cases of flu and common cold

Erythromycin was an early example. It was introduced as an alternative to penicillin for the treatment of Staphylococcus aureus in Boston City Hospital in the early 1950s. It was completely withdrawn after less than a year because 70% of all the S. aureus isolates were found to have become erythromycin resistant. The same was observed with a tetracycline and chloramphenicol and, subsequently, with other antibiotics.

Unfortunately, the colossal need for these valuable drugs has had a significant environmental downside. In the 60 years since their introduction, millions of metric tons of antibiotics have been produced and employed for a wide variety of purposes. Improvements in production have provided increasingly less expensive compounds that encourage nonprescription and off-label uses. The cost of the oldest and most frequently used antibiotics is (probably) mainly in the packaging, and this is really ironic if we look back in history when pandemic infections stroke mankind.

What happened during the evolution of bacteria over several billions of years cannot be compared to the phenomenon of antibiotic resistance development and transfer over the last century. The existing processes of gene acquisition, transfer, modification, and expression that were in place ever since are expanding and accelerating in the modern biosphere. The way how bacteria exchange genes (plasmids, phages, and transformation) are well known from the lab. But in the natural environment other processes may exist. For example, bacterial cell-cell fusion might be favored in complex mixed microbial communities.

Another important point, we don’t know the pathway from an environmental gene to a clinical resistant gene yet. We can only assume that this road is easy to walk on for those genes.

One more practical remark for you if you have to take antibiotics: Especially at sub-inhibitory concentrations, the process of antibiotic resistance development may be facilitated.

What could be done to slow down the detrimental signs of resistance development?

Over the years, many different solutions have been proposed by experts and all the major international health groups (e.g., WHO and the CDC). Among the proposals for action are strict controls on antibiotic use by humans. Here we clearly enter the territory of politics. I intentionally stay out of this area because here discussions never end, and the various agendas get blurry and disarrayed. I cannot contribute anything of influence that would really matter on a larger scale. I may only dare to advise you to question yourself before using antibiotics, and question it, if you feel the prescription was a doctor’s quick and easy pick.

Most infections are first of all viral origin, then antibiotics are not justified. If you come down with an acute virus infections it takes you up to one week to recover. Fever shouldn’t scare you. A healthy circulatory system can easily cope with 39°C and a heart frequency over 100 beats for a week or even more. Homespun remedies are not part of this article, but play an important role. We should definitely rediscover and learn about the remedies of our ancestors.

If it comes to non-antibiotic approaches for the treatment of bacterial diseases, Biestmilch is a serious option stimulating or recruiting the innate immune system of the host. Recent advances in our understanding of the roles of the human gut microbiome in innate immunity underscore the role of Biestmilch as an other therapeutic option. At least you should consider taking it together with antibiotics. The debris antibiotics leave behind has to be cleaned up by the immune system. Biestmilch empowers the immune system to do so more effectively.

This is the end of a fragment on a very complex topic.

Literature

Hawkey PM, Jones AM: The changing epidemiology of resistance. Journal of Antimicrobial Chemotherapy, 64: Suppl.1, i3–i10, 2009

Davies J,  Davies D: .Origins and Evolution of Antibiotic Resistance. Microbiol. Mol. Biol. Rev. 74(3):417, 2010

Levy St B, Marshall B: Antibacterial resistance worldwide: causes, challenges and responses. Nature supplement, 10(12): 122-129, 2004

The colostrum study I attached here suggests that Biestmilch/colostrum is superiour to the vaccines in preventing a flu.

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The best tumor therapy is prevention

Because most cancers develop slowly over decades, prevention should stand in first place today. By prevention, we mean influencing the environment of the genetically altered cell. Prevention comprises healthy and good quality food. Eating is the most important environment modulator, closely followed by regular exercise, i.e. sport, because physical exercise activates the immune system and suppresses inflammatory processes that are smoldering in the body. It is also very important to not eat too much, i.e. restrict calories.

Biestmilch belongs to the food plan (it is a foodstuff). It is a kind of immune serum, a substance that is able to calm down chronic inflammatory tissue.

Biestmilch can modulate the inflammatory environment of the tumor

The inflammatory response should actually contribute towards removing the tumor cells. However, in the case of humans with tumors, the inflammatory response is unproductive. Inflammatory and anti-inflammatory processes are no longer in balance but have displaced towards the chronic inflammation. It is typical for the environment of the tumor that receptors become insensitive meaning no effective anti-tumor response is generated.

Today, the therapeutic challenge principally lies in normalizing the deregulated inflammatory network in such a way that the result is a regular moderate inflammatory response. Thanks to its diversity, Biestmilch as one of the very few substances available has this potential. Furthermore, it can stabilize the immune system for chemotherapy to such an extent that subsequent metastasizing may be delayed or even prevented, and side-effects of the immunosuppressant treatment mitigated.

How to take Biestmilch:

You should take Biestmilch every day. Make it part of your food plan. You don’t interrupt the intake.

Take 900 mg every day. If you are taking Biestmilch as preparation for chemotherapy or in addition to that, increase the amount to 3 x 900 mg every day. After chemotherapy reduce step by step to 900 mg or 600 mg. In the case of a repeat chemo-cycle, please increase the dosage again to 3 x 900 mg.

1
One hypothesis reads as follows: The cell reveals a gene defect that can no longer be repaired. For this reason, the external appearance of the cell deviates from that of the normal cell. Such a cell no longer divides itself up asymmetrically into a cell with a function (effector cell), which depends upon which organ or apparatus it is allocated to and into a stem cell but symmetrically into two cells with functions. Yet, it is not a tumor cell. As long as the environment surrounding the cell suppresses cell proliferation, a tumor does not develop.

2
If, however, a carcinogen or a chronically inflamed environment affects the cell to the extent that the brake preventing cell proliferation is released, then the cell begins to proliferate in an uncontrolled manner. The result is a mass of cells such as polyps in the colon or papilloma in the skin. For a so-called malignant tumor to develop, a number of additional genetic or cellular changes must occur. It’s not until now that the step towards the tumor becoming malignant follows.

3
Another hypothesis – worded by Potter back in 1978 – explains the emergence of a tumor as being a blockage of cell development on their way from the stem cell to the cell that is equipped with the function determined for that cell. These cells still carry a large number of options for developing into the various effector cells. An interruption to this development can happen at any stage of this process. Influences from the cell’s environment can speed up cell division and prevent the normal death of the cell.

4
You have probably often come across the term oncogene. More than 100 oncogenes have already been identified. Oncogenes are DNA parts that serve as the template for the synthesis of protein substances with differing tasks like growth factors, receptors, signal-transferring molecules.

5
The tumor suppressor genes have a quasi contrary task to the oncogenes. They form the template for the growth of inhibitive factors such as bridging molecules. These are structural proteins between cell membranes forming channels for the direct transfer of small molecules and ions between the cells. These bridging molecules are central structures of monitoring growth and cell differentiation. If a cell with  such a defect gene has still got bridging connections, it is able to develop in its target cell to a certain extent. Its direct contact to the other cells in the network inhibits uncontrolled proliferation.

In tumors, the bridging molecules are usually missing. That means that the cell loses an important component for its interaction with the environment. An activated oncogene and an inactivated suppressor gene can permanently stimulate growth.

The objective of the research is to make tumor treatment that is currently very poor more specific and targeted.

For references and more on tumor development in specific, please read part one.

10 years of experience allow us to say that Biestmilch is a powerful tool in the treatment of cancer. Immune and inflammatory parameters return back to normal. CD4/CD8 ratio normalizes. Side-effects of chemotherapy are far less pronounced in many cases. This comprises hair loss, nausea, gut issues, mood swings etc.

Here, you can find texts I wrote about this natural remedy that in my opinion cannot be topped when it comes to the strength and diversity of its effect. Biestmilch is not harmful to you, doesn’t hurt you. In order to understand Biestmilch, you will have to say goodbye to conventional ways of thinking. There’s no need to distance yourself from scientific knowledge but you do have to move along the borders of science where rethinking takes place and new things come to life.

Part I
Tumor – See the opportunities
A tumor is not an accumulation of malignant cells

You may find that sounds like a provocation. I would now like to tell you why that is not the case and why this scientific observation uncovers great opportunities for you.
Scientists have recently recognized that the notion of a tumor consisting of an accumulation of malignant cells, which have withdrawn themselves from growth control, does not apply. This view should thus to be discarded and become history. Unfortunately, medicine has not yet it adopted.

A network of regulatory circuits controls the balance of the cells’ proliferation and differentiation

Cancer cells display defects within their regulatory circuits that control cell proliferation, balance growth and quiescence, guide regeneration and cell death. These signalling processes of maintaining the cell’s balance are complexly intertwined and can be disturbed or disrupted in many ways. This is why we can differentiate among more than 100 types and subtypes of tumors within one single organ. In other words, no one type of cancer resembles the other.
How many regulatory circuits in a target cell need to be broken that control processes cannot stop a tumor from growing anymore and whether the same or similar regulatory circuits in every tumor cell are affected in the various tumors remains unknown to this day. Which regulatory circuits in the cells run independently from the environment and which are coupled to signals from the micro-environment is likewise unexplored. Whether the large number of cancer-related genes can be tied to certain regulatory circuits also needs more research.

A genetic defect alone does not necessarily lead to a tumor developing

It can take decades for a tumor to reach the size of medical significance, i.e. until symptoms become apparent. Tumors usually grow very slowly and, in addition to that, a series of unfortunate coincidences must concur. A defect in the DNA is not sufficient to make a tumor develop and that is why a tumor is not simply a collection of malignant cells whose growth proceeds in an aggressive and uncontrolled way. And because of this fact, a suitable lifestyle that creates a healthy environment for the cell can very much help to prevent the development of a tumor.

For a tumor to start growing, a number of factors must coincide
Disorders of the cell biology can take place on the level of the cell core, the cytoplasm, the receptors, the extra-cellular matrix and the neighboring cells. The underlying processes are arranged on a time basis in 3 phases: 1) the initiation of the DNA, 2) the promotion in the intra- and extra-cellular environment and 3) the progression through tumor-specific communication processes beyond the primary tumor.
First of all, the cell experiences a genetic change, that is initiated. It can linger or pause in this state for decades on end. This means a tumor never grows. So, as you see, a genetic defect does not suffice to produce a tumor.
However, if such a cell experiences an irritation such as the influence of a carcinogen or a chronic inflammatory change to its environment, then the genetic defect may manifest in the development of a tumor. A chronic inflammatory environment gives this genetically weak cell a growth advantage over other cells.

The tumor cell grows independently by loosing contact with their neighbor cells

No normal cell can multiply itself without stimulating signals. In contrast, a tumor cell grows independently; it loses its coupling to the environment. Many oncogenes function by copying normal growth signals. Healthy cells are connected by an array of molecules called connexins.
These bridging molecules are essential for the communication among cells. In contrast pluri- or omnipotent stem cells are characterized by not carrying such connexins on their surface. Thus, they have no bridges for communicating with other cells. These bridging molecules are significantly involved in controlling the growth of cells and tissues. Communication is thus an important control process.

Characteristics of a cancer cell:
1. Self-sufficient generating its own growth signals
2. Insensitive towards signals limiting and regulating growth
3.Undermining the process of cell death (apoptosis)
4. Endless potential for proliferation
5. Maintaining the formation of vessels
6. Penetrating into the tissue and metastasizing

The cell’s environment is just as important as the cell itself

In science, one speaks of epigenetic processes, which play a central role in the development of tumors. As you know, the cell consists of the nucleus in which chromosomes, the DNA, the genetic material so to say are located, of the cytoplasm surrounding the nucleus, in which a large number of molecule assemblies form structures that are necessary for the cell to live and to become what it is and what it does. The cell as a whole is surrounded by a membrane just like the nucleus is. All structures that form this kind of cell have, on the one hand, parts which have a very flexible shape (receptors, ligands) and continuously send and receive signals. On the other hand, they fulfill certain tasks in the cell such as cell respiration or protein biosynthesis. Thus a stream of signals flows through the cell, which leads from the cell’s nucleus to the environment surrounding the cells and back. In simple terms, it is a fabric of thousands of feedback loops infinitely sending signalls from the inside to the outside and back.
The resulting signal patterns determine the specific functional state of the cell. Irrespective of what function a cell has, in principle, all cells work according to the same principle.

Working in basically the same way a cell is susceptible to change either for the good or the bad on various levels in terms of  place and time.
Cell growth is thus not a phenomenon that is controlled solely by the cell’s nucleus and its genetic material. The cell is closely connected to its environment, exchange is narrow and intensive. Not only do signals/impulses/messages from the interior of the cell reach the cell’s surroundings, thus changing the cell’s state, but signals/impulses/messages from the environment likewise influence the cell’s and the nucleus function and activity. In this way, the cells and the space among them form an entity of brisk exchange.

Tumors only develop in chronic inflammatory environments

Virchow saw a correlation between inflammation and tumor back in 1863. Ever since, research has been changing in such a way that can barely be compared to those times. And yet, this postulate gained more relevance than ever. In the meantime we know from some chronic viral infections that they can make the way for tumors to develop. And the same applies to chronic inflammations like rheumatism or chronic inflammatory bowel diseases.
Inflammations are usually self-limiting processes. With a fine-tuned immune response, the immune system makes sure that inflammatory and anti-inflammatory processes are balanced and ultimately lead to healing.

Tumor patients display a weakened (suppressed) immunity. When a tumor starts to grow or metastasize, then it has usually already undermined the immune system with its monitoring strategies. An intact immune system patrols the body and removes the cells that are no longer behaving properly.
Dvorak recognized the similarities between wound healing and tumors back in 1986. In contrast to a tumor, a wound heals itself. In a tumor, the process continues by factors being released unremittingly, which maintain the inflammation. As is the case with wound healing, the formation of vessels for a tumor to emerge plays is crucial, for a tumor that measures more than one to two millimeters, blood vessels are vital.

To put it a nutshell:

In order for a malignant tumor to start growing, an external or internal trigger, an inflamed environment and some damage to the DNA must concur. An improbable event for an individual? Many malignant tumors are triggered off by infections. A history of infection can be assigned to more than 15% of all tumors worldwide; that is more than 1.2 million cases a year. Thus, tumors develop as the result of a multi-leveled process, which leads from an initial benign change of the cells to an invasive and then metastasizing disease. This process takes many years until it has fully developed. The long period this process requires strongly implies that it has to assert itself against a background of strict and diversified control processes that are supposed to prevent anarchical cell behavior.

It is thus probable that a certain environment tied to a genetic disposition changes the cells to such an extent that they become more receptive for endogenous and exogenous carcinogenic influences. It may depend on whether the carcinogens can actually trigger off tumor growth and how long it takes until the process is clinically apparent.

If you want to know more about the hypotheses scientists are currently working with, please read part II of the article, part III gives you some guidelines on how you can administer Biestmilch in tumor patients.

Sources of literature
Coussens LM, Werb Z: Inflammation and cancer. Nature, 420: 860 – 867, 2002.
O‘Byrne KJ, Dalgleish AG: Chronic activation and inflammation as cause of malignancy.
British Journal of Cancer, 85 (4): 473 – 483, 2001
Shamgar B-E: The promotion of tumor metastasis by surgery and stress: immunological basis and implications for psychoneuroimmunology. Brain, Behaviour and Immunitiy, 17: 27 – 36, 2003
Lotem J, Sachs L: Epigenetics wins over genetics: induction of differentation in tumor cells.
Cancer Biology, 12: 339 – 346, 2002
Trosko JE: The role of stem cells and gap junctional intercellular communication in caringenesis. Journal 
of Biochemistry and Molecular Biology, 36 (1): 
43 – 48, 2003
Trosko JE: Chang CH-Ch, Upham BL, et al.: 
Ignored hallmarks of carcinogenesis: stem cells and cell-cell communication. Ann. N.Y. Acad. Sci., 1028: 192 – 201, 2004
Hanahan D, Weinberg RA: The hallmarks of cancer. Cell, 100: 57 – 70, 2000